Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia
Background In patients with severe eosinophilic asthma, local maturation rather than
systemic recruitment of mature cells might contribute to persistent airway eosinophilia.
Group 2 innate lymphoid cells (ILC2s) are a major source of type 2 cytokines (IL-5 and IL-13)
and can facilitate eosinophilic inflammatory responses in mouse models of asthma in the
absence of CD4+ lymphocytes. This study investigated the potential role of ILC2s in driving
chronic airway eosinophilia in patients with severe asthma, despite regular high-dose oral …
systemic recruitment of mature cells might contribute to persistent airway eosinophilia.
Group 2 innate lymphoid cells (ILC2s) are a major source of type 2 cytokines (IL-5 and IL-13)
and can facilitate eosinophilic inflammatory responses in mouse models of asthma in the
absence of CD4+ lymphocytes. This study investigated the potential role of ILC2s in driving
chronic airway eosinophilia in patients with severe asthma, despite regular high-dose oral …