[HTML][HTML] Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors
DN Lavery, MA Villaronga, MM Walker, A Patel… - Journal of Biological …, 2011 - ASBMB
The Hairy/Enhancer-of-split-related with YRPW-like motif (HEY) family of proteins are
transcriptional repressors and downstream effectors of Notch signaling. We previously
reported that HEY1 and HEY2 selectively repress androgen receptor (AR) signaling in
mammalian cell lines and have shown that in human tissue HEY1 is excluded from the
nuclei in prostate cancer but not benign prostatic hyperplasia. We have now characterized a
third member of this family, HEYL, which is a more potent repressor of AR activity. HEYL …
transcriptional repressors and downstream effectors of Notch signaling. We previously
reported that HEY1 and HEY2 selectively repress androgen receptor (AR) signaling in
mammalian cell lines and have shown that in human tissue HEY1 is excluded from the
nuclei in prostate cancer but not benign prostatic hyperplasia. We have now characterized a
third member of this family, HEYL, which is a more potent repressor of AR activity. HEYL …
