Notch receptors in a given cell are activated by cell surface ligands in neighbouring cells but
can also be inhibited by the ligands present within the same cell. This process is known as
cis-inhibition of Notch. Additionally, reciprocal cis-inhibition of the ligands by Notch has also
been observed, albeit to a limited extent. Here, we review the mechanisms, functional
relevance and potential implications of these cis-inhibitory interactions for Notch-mediated
fate decisions.