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Heroin addiction engages negative emotional learning brain circuits in rats
Stephanie A. Carmack, … , Elliot A. Stein, Leandro F. Vendruscolo
Stephanie A. Carmack, … , Elliot A. Stein, Leandro F. Vendruscolo
Published June 3, 2019; First published March 26, 2019
Citation Information: J Clin Invest. 2019;129(6):2480-2484. https://doi.org/10.1172/JCI125534.
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Categories: Concise Communication Neuroscience

Heroin addiction engages negative emotional learning brain circuits in rats

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Abstract

Opioid use disorder is associated with the emergence of persistent negative emotional states during drug abstinence that drive compulsive drug taking and seeking. Functional magnetic resonance imaging (fMRI) in rats identified neurocircuits that were activated by stimuli that were previously paired with heroin withdrawal. The activation of amygdala and hypothalamic circuits was related to the degree of heroin dependence, supporting the significance of conditioned negative affect in sustaining compulsive-like heroin seeking and taking and providing neurobiological insights into the drivers of the current opioid crisis.

Authors

Stephanie A. Carmack, Robin J. Keeley, Janaina C. M. Vendruscolo, Emily G. Lowery-Gionta, Hanbing Lu, George F. Koob, Elliot A. Stein, Leandro F. Vendruscolo

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ISSN: 0021-9738 (print), 1558-8238 (online)

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